产品货号：
Z36502
中文名称：
RBCK1抗体
英文名称：
Anti-RBCK1 Antibody (Clone#1839CT718.19.54)
产品规格：
50μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-RBCK1 Antibody (Clone#1839CT718.19.54) |
| 指标别名 | C20orf18,HBV associated factor 4,HOIL 1,HOIL1,RBCK1,RBCK2,RING finger protein 54,RNF54,UBCE7IP3,XAP3,XAP4,ZRANB4 |
| 克隆性 | Monoclonal |
| 检验物种 | human |
| 应用范围 | WB |
| 基因名称 | RBCK1 |
| 克隆号 | 1839CT718.19.54 |
| 抗体来源 | Mouse |
| 免疫原 | This RBCK1 (UBCE7IP3) antibody is generated from a mouse immunized with a recombinant protein of human RBCK1 (UBCE7IP3). |
| 计算分子量 | 58kDa |
| 成分 | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
| 纯化方式 | This antibody is purified through a protein G column,followed by dialysis against PBS |
| 保存条件 | Maintain refrigerated at 2～8℃ for up to 2 weeks.For long term storage,store at -20℃ in small aliquots to prevent freeze-thaw cycles. |
| 背景资料 | E3 ubiquitin-protein ligase,which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes,such as UBE2L3/UBCM4,and then transfers it to substrates.Functions as an E3 ligase for oxidized IREB2 and both heme and oxygen are necessary for IREB2 ubiquitination.Promotes ubiquitination of TAB2 and IRF3 and their degradation by the proteasome.Component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF- kappa-B activation and regulation of inflammation.LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways.Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation.LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF- RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex.Together with FAM105B/otulin,the LUBAC complex regulates the canonical Wnt signaling during angiogenesis.Binds polyubiquitin of different linkage types. |
| Uniprot ID | Q9BYM8 |
相关搜索：RBCK1抗体，RBCK1单抗，Anti-RBCK1 Antibody (Clone#1839CT718.19.54)